Table 2 Subgroup analysis of the acceptance rate of TPT in Chinese children and adolescents.

From: Acceptance of preventive therapy for latent tuberculosis infection in Chinese children and adolescents: a systematic review and meta-analysis

Subgroup analysis type

No. of studies

Effect size

M

Heterogeneity

ES [95%CI]

PES

I2 (%)

PH

All studies

31

0.640 [0.569, 0.709]

< 0.001

REM

95.770

< 0.001

Subgroup analysis by region

Eastern region

17

0.615 [0.509, 0.717]

< 0.001

REM

95.181

< 0.001

Central region

8

0.765 [0.698, 0.825]

< 0.001

REM

91.045

< 0.001

Western region

6

0.531 [0.284, 0.771]

< 0.001

REM

96.688

< 0.001

Northeastern region

1

0.656 [0.527, 0.771]

< 0.001

NA

NA

NA

Subgroup analysis by research setting

Routine screening

11

0.522 [0.398, 0.645]

< 0.001

REM

97.313

< 0.001

School outbreak screening

18

0.663 [0.551, 0.767]

< 0.001

REM

94.433

< 0.001

Household contact screening

2

0.802 [0.749, 0.850]

< 0.001

REM

55.786

0.046

Subgroup analysis by preventive therapy criteria

TST ≥ 10 mm or strong reaction

3

0.559 [0.266, 0.832]

< 0.001

NA

NA

NA

TST ≥ 15 mm or strong reaction

22

0.615 [0.514, 0.711]

< 0.001

REM

95.374

< 0.001

TST ≥ 20 mm or strong reaction

3

0.657 [0.347, 0.909]

< 0.001

NA

NA

NA

IGRA positive

1

0.805 [0.743, 0.860]

< 0.001

REM

69.512

0.020

TST ≥ 15 mm or strong reaction

or IGRA positive

2

0.572 [0.525, 0.618]

< 0.001

NA

NA

NA

Subgroup analysis by regimen

INH

8

0.632 [0.505, 0.750]

< 0.001

REM

93.948

< 0.001

INH and RIF

15

0.563 [0.445, 0.678]

< 0.001

REM

97.077

< 0.001

INH and RFT

10

0.765 [0.695, 0.829]

< 0.001

REM

79.353

< 0.001

Subgroup analysis by duration

3 months

24

0.634 [0.544, 0.719]

< 0.001

REM

96.067

< 0.001

6 months

9

0.658 [0.539, 0.767]

< 0.001

REM

94.669

< 0.001

Subgroup analysis by dosage frequency

Once a day

23

0.589 [0.501, 0.674]

< 0.001

REM

96.341

< 0.001

Twice a week

10

0.765 [0.695, 0.829]

< 0.001

REM

79.353

< 0.001

Subgroup analysis by study start year

Before 2017

17

0.582 [0.476, 0.684]

< 0.001

REM

95.851

< 0.001

Since 2017

14

0.693 [0.592, 0.786]

< 0.001

REM

95.839

< 0.001

  1. ES effect size, CI confidence interval, M Model, REM random effects model, NA not available.
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