Fig. 2 | Scientific Reports

Fig. 2

From: BT-11 targets the LANCL2 pathway to attenuate cognitive deficits and hippocampal pathology in Alzheimer’s transgenic rats

Fig. 2

BT-11 did not improve spatial learning in TgF344-AD females. All females showed learning across six trials with a significant trial effect. The measure used to analyze this data was percent (%) time in the target zone during a 600 s trial. There were no significant genotype differences between (a) WTNT and TGNT, (b) WTTR and TGTR, nor treatment differences between (c) TGNT and TGTR, (d) WTNT and WTTR. (e) Representative track tracings of a WTNT and a TGNT female performance for trial 3. Red lines represent the bounds of the shock zone and red circles represent each shock that was given. Two-way ANOVA with Tukey’s post hoc test with GraphPad Prism 9 software were used, **** P < 0.0001. EA—early acquisition; AP—asymptotic performance; WTNT—wild-type not treated; TGNT—transgenic not treated; WTTR— wild-type BT-11-treated; TGTR—transgenic BT-11-treated; t = training effect.

Back to article page