Table 1 Physico-chemical properties of spray dried ATR-Chitosan Nanoparticles. ATR- Atorvastatin calcium, SAS- spray dried Atorvastatin calcium with 0.7 mm nozzle, ACS1 to ACS3- spray dried Atorvastatin calcium with different ratios of Chitosan using 0.7 mm Nozzle, SAO- spray dried Atorvastatin with 1 mm nozzle, ACO1 to ACO3 - spray dried Atorvastatin calcium with different ratios of Chitosan using 1 mm Nozzle.
Formulation code | Nozzle Size | Drug to Polymer Ratio | Particle Size (nM) | PDI | Zeta Potential (mV) | Avg Drug Content (%) |
|---|---|---|---|---|---|---|
Pure ATR | - | - | - | - | -14.8 | - |
SAS | 0.7 | - | - | - | -17.8 | - |
ACS1 | 0.7 | 1:0.5 | 248.2 ± 17.58 | 0.005 | -4.63 | 101.65 ± 2.39 |
ACS2 | 0.7 | 1:1 | 266.4 ± 16.4 | 0.003 | -2.75 | 114.36 ± 5.43 |
ACS3 | 0.7 | 1:2 | 313.7 ± 27.76 | 0.007 | -2.86 | 87.95 ± 10.03 |
SAO | 1 | - | 190.88 ± 17.7 | 0.008 | -23 | - |
ACO1 | 1 | 1:0.5 | 309.3 ± 26.75 | 0.007 | -8.31 | 93.22 ± 13.32 |
ACO2 | 1 | 1:1 | 316.4 ± 42.44 | 0.017 | -2.74 | 79.66 ± 1.50 |
ACO3 | 1 | 1:2 | 329 ± 36.68 | 0.012 | -1.6 | 85.3 ± 0.7 |
