Table 1 Diagnosis indexes for the one-cut-off and two-cut-off models in each validation cohort.
From: Clinical validation of new alzheimer disease diagnosis tools based on plasma p-Tau217
Cohort | Indexes | One-cut-off model | Two-cut-off model | ||
|---|---|---|---|---|---|
CI 95% | CI 95% | ||||
Hospital Universitari i Politècnic La Fe cohort | AUC | 0.904 | 0.853–0.955 | - | - |
Sensitivity (%) | 82.7 | 74.3–88.8 | 94.9 | 87.5–98.0 | |
Specificity (%) | 83.1 | 71.5–90.5 | 88.2 | 73.4–95.3 | |
PPV (%) | 89.6 | 81.9–94.2 | 94.9 | 87.5–98.0 | |
NPV (%) | 73.1 | 61.5–82.3 | 88.2 | 73.4–95.3 | |
Accuracy (%) | 82.8 | 76.3–87.8 | 92.9 | 86.5–96.3 | |
Hospital Doctor Peset cohort | AUC | 0.955 | 0.879-1 | - | - |
Sensitivity (%) | 95.5 | 78.2–99.2 | 100.0 | 82.4–100.0 | |
Specificity (%) | 88.9 | 56.5–98.0 | 80.0 | 37.6–96.4 | |
PPV (%) | 95.5 | 78.2–99.2 | 94.7 | 75.4–99.1 | |
NPV (%) | 88.9 | 56.5–98.0 | 100.0 | 51.0-100.0 | |
Accuracy (%) | 93.5 | 79.3–98.2 | 95.6 | 79.0-99.2 | |
ADNI cohort | AUC | 0.727 | 0.623–0.822 | - | - |
Sensitivity (%) | 79.2 | 65.7–88.3 | 89.5 | 75.9–95.8 | |
Specificity (%) | 47.7 | 36.0-59.6 | 39.5 | 25.6–55.3 | |
PPV (%) | 52.8 | 41.4–63.9 | 59.6 | 46.7–71.4 | |
NPV (%) | 75.6 | 60.7–86.2 | 78.9 | 56.7–91.5 | |
Accuracy (%) | 61.1 | 51.8–69.5 | 64.5 | 53.3–74.3 | |
