Table 4 ORs for candidate risk factors for PDPH at 24 h and seven days.

From: Protocol to avoid post-dural puncture headache after large-volume cerebral spinal fluid extraction in a prospective observational memory clinic study

Risk factorsa

PDPH at 24 hb

PDPH at 7 db

  

P value

OR (95% CI)

 

P value

OR (95% CI)

Biological sex: 1147 LPs

Male

37/481 (7.7)

0.068

0.68 (0.45–1.02)

21/481 (4.4)

0.675

0.88 (0.50–1.54)

Female

73/666 (11.0)

1 (reference)

33/666 (4.9)

1 (reference)

BMI: 1147 LPs

 > 18.5–24.9

4/345 (12.2)

0.021

1 (reference)

25/345 (7.3)

0.116

1 (reference)

25–29.9

47/528 (8.9)

0.70 (0.42–1.09)

20/528 (3.8)

0.50 (0.27–0.92)

30–34.9

13/203 (6.4)

0.49 (0.26–0.94)

6/203 (2.9)

0.39 (0.16–0.96)

35–39.9

4/58 (6.9)

0.53 (0.18–1.55)

3/58 (5.2)

0.70 (0.20–2.84)

 > 40

4/13 (30.8)

3.20 (0.94–10.84)

0/13 (0)

0.0 (0.00–0.00)

History of chronic headachec

Yes

21/193 (10.9)

0.505

1.18 (0.71–1.95)

11/193 (5.7)

0.458

1.28 (0.65–2.53)

No

89/954 (9.3)

 

1 (reference)

54/954 (5.7)

 

1 (reference)

History of migraine: 1147 LPs

Yes

24/180 (13.3)

0.074

1.57 (0.97–2.54)

6/180 (3.3)

0.444

0.66 (0.28–1.56)

No

86/967 (8.9)

1 (reference)

48/967 (5.0)

1 (reference)

History of chronic pain, 1147 LPs

Yes

39/286 (13.6)

0.007

1.81 (1.19–2.76)

18/286(6.3)

0.145

1.56 (0.87–2.81)

No

66/824 (8.0)

 

1 (reference)

34/824 (4.1)

 

1 (reference)

Positioning, 1138 LPs

Seated

17/208 (8.2)

0.515

1 (reference)

8/208 (3.8)

0.591

1 (reference)

Lateral decubitus

92/930 (9.9)

 

0.81 (0.47–1.39)

46/930 (4.9)

 

0.77 (0.36–1.66)

Puncture site, 1143 LPs

L2-L3

1/14 (7.1)

0.002

1.07 (0.14–8.40)

1/14 (7.1)

0.421

1.81 (0.23–14.48)

L3-L4

33/528 (6.3)

 

1 (reference)

20/528 (3.8)

 

1 (reference)

L4-L5

63/527 (12.0)

 

2.04 (1.31–3.16)

29/527 (5.5)

 

1.47 (0.82–2.64)

L5-S1

12/73 (16.4)

 

2.95 (1.49–6.02)

4/73 (5.5)

 

1.47 (0.49–4.44)

Number of attempts, 1143 LPs

1 attempt

94/916 (10.3)

0.111

1 (reference)

48/916 (5.2)

0.234

1 (reference)

2–4 attempts

12/202 (5.9)

 

0.55 (0.30–1.03)

5/202 (2.5)

 

0.46 (0.18–1.17)

 > 4 attempts

3/25 (9.5)

 

1.19 (0.35–4.06)

1/25 (4.0)

 

0.76 (0.10–5.70)

  1. Data are number (percentage) unless otherwise indicated as mean (SD).
  2. aThe total number of LPs for which data were available varied between variables.
  3. bFrequency data are number (percentage).
  4. cGeneral non-migraine headache.
  5. OR, odds ratio; PDPH, post-dural puncture headache; LP, lumbar puncture.
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