Table 5 Relative fold expression of inflammasome-related genes in LPS-activated U937 macrophages following drug treatment, normalized to B2M gene (n = 3).

From: Design and biological evaluation of mesalamine–NSAID hybrids targeting the NLRP3 inflammasome: a multi-target strategy for ulcerative colitis therapy

Gene

LPS (Control)

Mesalamine

D3

D4

B2M

1.005

1.303

1.229

1.209

IL1B

1.802

0.671

0.736

1.386

NLRP3

2.011

0.532

0.920

1.498

Caspase-1

0.213

0.324

0.574

0.765

IL-18

1.621

15.096

2.598

2.192

Caspase-8

0.325

25.253

0.413

0.562

Back to article page