Fig. 2 | Scientific Reports

Fig. 2

From: Clostridium leptum attenuates allergic airway inflammation via tDC‒Treg axis activation in a murine model of gut dysbiosis-associated asthma

Fig. 2

CL regulated the gut microbiota of antibiotic-induced mice. (A) Venn diagram of the average numbers of operational taxonomic units (OTUs) and overlapping OTUs in different mouse groups; (B) Sample-level clustering in different mouse groups. The length of the branch represents the distance between the samples. (C) Observed index, Chao 1index, ACE index, Shannon index, Simpson index, and Pielou index; (D) Principal coordinate analysis (PCoA) of each group; Nonmetric multidimensional scaling (NMDS) analysis of each group. (E) At the phylum level, the top 8 with the highest abundance; At the class level, the top 8 with the highest abundance; At the order level, the top 12 with the highest abundance; At the family level, the top 19 with the highest abundance. (F,G) Effect Size (LEfSe) analysis of the microbiota in different mouse groups. (H) PICRUSt2 (Phylogenetic Investigation of Communities by Reconstruction of Unobserved States) based on KEGG gene family database between IDFAA_CL group and IDFAA group, (I) PICRUSt2 based on KEGG gene family database in different mouse groups. Significant differences in LDA scores > 2.0 and FDR < 0.05 are shown in Biomakers, i.e., Biomakers with statistical differences.

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