Table 1 Descriptive statistics of the analytical sample by late-onset epilepsy and Alzheimer’s disease status, full UCLA patient population (N = 416,212)a.
From: Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer’s disease
Late-onset epilepsy | Alzheimer’s disease | |||||
|---|---|---|---|---|---|---|
Cases | Controls | P-value | Cases | Controls | P-value | |
N = 7,351 | N = 408,861 | N = 6,706 | N = 409,506 | |||
Primary outcome(s) | ||||||
Alzheimer’s disease (Yes) | 571 (7.8%) | 6,135 (1.5%) | < 0.001* | 6,706 (100%) | 0 (0%) | - |
Late onset epilepsy (Yes) | 7,351 (100%) | 0(0%) | - | 571 (8.5%) | 6,780 (1.7%) | < 0.001* |
Demographics | ||||||
Age at first visit (in years) | 60.89 (11.44) | 60.10 (11.32) | < 0.001* | 65.75 (11.38) | 60.02 (11.30) | < 0.001* |
Age at last visit (in years) | 75.76 (7.37) | 72.30 (7.87) | < 0.001* | 81.68 (5.83) | 72.21 (7.81) | < 0.001* |
Sex (female) | 3,718 (51%) | 221,290 (54%) | < 0.001* | 4,060 (61%) | 220,948 (54%) | < 0.001* |
EHR record length (in years) | 14.87 (10.72) | 12.20 (9.84) | < 0.001* | 15.93 (10.89) | 12.19 (9.83) | < 0.001* |
Deceased (Yes) | 1,336 (18%) | 18,391 (4.5%) | < 0.001* | 1,601 (24%) | 18,126 (4.4%) | < 0.001* |
Health conditions | ||||||
Hypertension (Yes) | 5,031 (68%) | 143,043 (35%) | < 0.001* | 4,592 (68%) | 143,482 (35%) | < 0.001* |
Diabetes (Yes) | 1,624 (22%) | 43,392 (11%) | < 0.001* | 1,323 (20%) | 43,693 (11%) | < 0.001* |
Stroke (Yes) | 345 (4.7%) | 2,495 (0.6%) | < 0.001* | 572 (8.5%) | 2,268 (0.6%) | < 0.001* |
Hyperlipidemia (Yes) | 4,128 (56%) | 122,184 (30%) | < 0.001* | 3,864 (58%) | 122,448 (30%) | < 0.001* |
