Table 2 Descriptive statistics of the analytical sample by late-onset epilepsy and Alzheimer’s disease (AD) status, UCLA ATLAS patient population (N = 16,500)^a.

Primary outcome(s)

 Alzheimer’s disease (yes)

44 (6.7%)

332 (2.1%)

< 0.001*

376 (100%)

0 (0%)

-

 Late onset epilepsy (yes)

658 (100%)

0 (0%)

-

44 (12%)

614 (3.8%)

< 0.001*

Demographics

 Age at first visit (in years)

58.19 (10.36)

56.15 (11.60)

< 0.001*

62.08 (11.83)

56.09 (11.52)

< 0.001*

 Age at last visit (in years)

75.95 (6.77)

73.26 (7.59)

< 0.001*

82.01 (5.93)

73.16 (7.49)

< 0.001*

 Sex (female)

298 (45%)

7,794 (49%)

0.049*

207 (55%)

7,885 (49%)

0.02*

 EHR record length (in years)

17.76 (9.81)

17.11 (10.24)

0.03*

19.93 (10.92)

17.07 (10.20)

< 0.001*

 Deceased (yes)

141 (21%)

1,221 (7.7%)

< 0.001*

67 (18%)

1,295 (8.0%)

< 0.001*

Health conditions

 Hypertension (yes)

526 (80%)

10,849 (68%)

< 0.001*

296 (79%)

11,079 (69%)

< 0.001*

 Diabetes (yes)

188 (29%)

3,516 (22%)

< 0.001*

103 (27%)

3,601 (22%)

0.02*

 Stroke (yes)

48 (7.3%)

315 (2.0%)

< 0.001*

54 (14%)

309 (1.9%)

< 0.001*

 Hyperlipidemia (yes)

524 (80%)

11,589 (73%)

< 0.001*

304 (81%)

11,809 (73%)

< 0.001*

AD genetics

 APOE-ε4 count

0.5

< 0.001*

 0

483 (73%)

11,932 (75%)

211 (56%)

12,204 (76%)

 1

167 (25%)

3,707 (23%)

142 (38%)

3,732 (23%)

 2

8 (1.2%)

203 (1.3%)

23 (6.1%)

188 (1.2%)

 AD PRS with APOE region

0.11 (1.23)

0.06 (1.18)

0.2

0.28 (1.21)

0.05 (1.18)

< 0.001*