Table 3 Associations between Alzheimer’s disease (AD) and late-onset epilepsy (LOE), UCLA patient populationa.

From: Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer’s disease

 

AD ~ LOE

LOE ~ AD

N

HR [95% CI]

P-value

N

HR [95% CI]

P-value

UCLA full sample (N = 416,212)

 Basic modela

  Cox proportional hazard

415,623

6.86 (6.02, 7.81)

< 0.001*

415,364

6.31 (5.49, 7.25)

< 0.001*

  Fine and Gray

415,623

2.54 (2.12, 3.06)

< 0.001*

415,364

2.13 (1.36, 3.34)

0.001*

UCLA ATLAS sample (N = 16,500)

 Basic modela

  Cox proportional hazard

16,480

10.0 (6.43, 15.6)

< 0.001*

16,462

6.71 (4.06, 11.1)

< 0.001*

  Fine and Gray

16,480

3.55 (2.27, 5.55)

< 0.001*

16,462

2.26 (1.31, 3.88)

0.003*

 Adjusted for AD geneticsb

  Cox proportional hazard

16,480

10.2 (6.53, 15.9)

< 0.001*

16,462

6.55 (3.96, 10.9)

< 0.001*

  Fine and gray

16,480

3.77 (2.43, 5.83)

< 0.001*

16,462

2.20 (1.28, 3.81)

0.005*

  1. CI confidence interval, EHR electronic health record, HR hazard ratio.
  2. [a]Basic Model adjustments include age at first visit, sex, EHR record length, hypertension, diabetes, stroke, and hyperlipidemia status.
  3. [b]Additionally adjusted for APOE-ε4 count and AD polygenic risk score (without APOE region) in [b].
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