Table 5 Associations between shared Alzheimer’s disease (AD)-late-onset epilepsy (LOE) shared genetic risk score (GRS), APOE-ε4 count, and AD/LOE status, UCLA ATLAS patient population, with multi-task elastic net modeling testing sample (N = 2,002)a.
From: Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer’s disease
Phenotype | Variation explained | OR (95% CI) | P-value |
|---|---|---|---|
APOE-ε4 count | |||
AD or LOE | 1.44% | 1.90 (1.41, 2.53) | < 0.001* |
AD only | 7.57% | 4.31 (2.75, 6.78) | < 0.001* |
LOE only | 0.01% | 1.05 (0.70, 1.54) | 0.81 |
AD-LOE shared GRS (full) | |||
AD or LOE | 1.79% | 1.42 (1.22, 1.64) | < 0.001* |
AD only | 6.87% | 2.10 (1.64, 2.71) | < 0.001* |
LOE only | 0.29% | 1.16 (0.97, 1.38) | 0.1 |
AD-LOE shared GRS (without APOE) | |||
AD or LOE | 0.63% | 1.24 (1.06, 1.45) | 0.01* |
AD only | 0.72% | 1.28 (0.99, 1.66) | 0.056 |
LOE only | 0.49% | 1.21 (1.01, 1.46) | 0.04* |
