Table 6 Associations between Alzheimer’s disease (AD) and late-onset epilepsy (LOE), all of Us patient population (N = 52,493)a.

From: Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer’s disease

 

AD ~ LOE

LOE ~ AD

N

HR [95% CI]

P-value

N

HR [95% CI]

P-value

Basic modela

 Cox proportional hazard

52,319

3.95 (2.77, 5.63)

< 0.001*

52,206

2.96 (1.89, 4.61)

< 0.001*

 Fine and Gray

52,319

2.47 (1.69, 3.60)

< 0.001*

52,206

1.98 (1.22, 3.20)

0.005*

Adjusted for AD geneticsb

 Cox proportional hazard

52,319

3.96 (2.78, 5.64)

< 0.001*

52,206

2.96 (1.89, 4.62)

< 0.001*

 Fine and Gray

52,319

2.49 (1.71, 3.63)

< 0.001*

52,206

1.98 (1.22, 3.21)

0.001*

  1. CI confidence interval, EHR electronic health record.
  2. [a]Basic model adjustments include age at first visit, sex, EHR record length, hypertension, diabetes, stroke, and hyperlipidemia status.
  3. [b] Additionally adjusted for APOE-ε4 count and AD polygenic risk score (without APOE region) in [b].
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