Table 7 Associations between shared Alzheimer’s disease (AD)-late-onset epilepsy (LOE) shared genetic risk score (GRS), APOE-ε4 count, and AD/LOE status, all of Us patient population, genetic sample (N = 23,037)a.
From: Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer’s disease
Phenotype | Variation explained | OR (95% CI) | P-value |
|---|---|---|---|
APOE-ε4 count | |||
AD or LOE | 0.04% | 1.16 (1.01, 1.32) | 0.03* |
AD only | 0.46% | 1.98 (1.42, 2.84) | < 0.001* |
LOE only | < 0.01% | 1.04 (0.90, 1.20) | 0.59 |
AD-LOE shared GRS (full) | |||
AD or LOE | 0.10% | 1.09 (1.04, 1.14) | < 0.001* |
AD only | 2.02% | 1.54 (1.40, 1.69) | < 0.001* |
LOE only | < 0.01% | 1.01 (0.96, 1.06) | 0.80 |
AD-LOE shared GRS (without APOE) | |||
AD or LOE | 0.01% | 1.04 (0.95, 1.14) | 0.41 |
AD only | 0.06% | 1.17 (0.96, 1.42) | 0.12 |
LOE only | 0.02% | 1.09 (0.98, 1.20) | 0.11 |
