Table 3 Threshold effect analysis of CV on mortality in critically ill trauma patients using the two-piecewise linear regression model.

From: Association of glycemic variability with short- and long-term mortality in critically ill patients with trauma

Outcome

HR (95%CI)

P value

30-day mortality

Fitting model by standard linear regression

1.50 (1.24–1.83)

< 0.001

Fitting model by two-piecewise linear regression

  

Inflection point

12.2%

 

CV < 12.2%

0.82 (0.50–1.33)

0.420

CV > 12.2%

1.75 (1.39–2.21)

< 0.001

P for likelihood ratio test

 

0.019

1-year mortality

Fitting model by standard linear regression

1.29 (1.11–1.49)

0.001

Fitting model by two-piecewise linear regression

  

Inflection point

12.2%

 

CV < 12.2%

0.83 (0.59–1.17)

0.294

CV > 12.2%

1.49 (1.24–1.80)

< 0.001

P for likelihood ratio test

 

0.013

  1. CV: coefficient of variation (glycemic variability). HR: Hazard Ratio, CI: Confidence Interval.
  2. Adjusted for gender, age, race, vital signs (heart rate, SBP, DBP, MBP, respiratory rate, body temperature, SpO2), laboratory tests (hemoglobin, WBC, platelets, creatinine, BUN, PT, APTT, INR, sodium, potassium, calcium), comorbidities (diabetes, myocardial infarction, congestive heart failure, cerebrovascular disease, chronic pulmonary disease, renal disease, liver cirrhosis, malignant cancer), severity scores (Charlson Comorbidity Index, GCS, ISS, OASIS, SOFA), trauma variables (TBI, chest/abdominal/spinal/extremity/multiple trauma, trauma mechanism), and treatments (mechanical ventilation, vasoactive drugs, insulin, corticosteroid use, emergency surgery, blood transfusion).
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