Table 1 Antibodies.

From: Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry

Antibody

ka (1/Ms)

kd (1/s)

KD (nM)*

Ligand non-competitive antibodies

hGITR-nc-Ab-#1

7.08E + 05

4.45E-04

0.63 ± 0.01

hGITR-nc-Ab-#2

2.66E + 06

9.38E-04

0.35 ± 0.01

hGITR-nc-Ab-#4

1.96E + 06

1.22E-02

6.6 ± 0.79

Ligand-competitive antibodies

hGITR-lc-Ab-#3

7.72E + 05

2.58E-03

3.35 ± 0.09

  1. *Apparent affinity for ligand non-competitive Abs, true affinity for ligand-competitive Ab due to its monovalency.
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