Fig. 4 | Scientific Reports

Fig. 4

From: Treadmill training or caloric restriction delays aging-associated increase in urocortin 2-induced hyperthermia in middle-aged male Wistar rats

Fig. 4

Changes in core temperature (ΔTc) and oxygen consumption (ΔVO2) of 12 months old male Wistar rats of different intervention groups following an intracerebroventricular (ICV) injection of urocortin 2 (UCN2). Dark symbols indicate UCN2-treated, empty symbols indicate results of age-matched controls. (Panels a, b, and c show the results obtained in ad libitum fed sedentary NF12, ad libitum fed treadmilltrained TR12 and caloric restricted sedentary CR12 rats, respectively.) Control animals received pyrogen-free saline (PFS). Asterisks indicate significant differences between the UCN2-treated and control animals shown by repeated-measures ANOVA. Number of animals per group: TR12 treated n = 10, TR12 control n = 10, NF12 treated n = 8, NF12 control n = 8, CR12 treated n = 10, CR12 control n = 8.

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