Fig. 7
CCR8 deficiency alters immune cell interactions and gene expression in skin microenvironment. (A) UMAP plot showing the clustering of immune cell populations based on scRNA-seq data. Each cluster is represented by a different color, with each number corresponding to a distinct cell identity. (B) UMAP plot depicting the immune cell distribution in control, Anti_Ccr8, and KO_Ccr8 groups. (C) Bar graph showing the distribution of different immune cell types across the Anti_Ccr8, Control, and KO_Ccr8 groups. (D) Dot plot showing the expression of specific markers in various immune cell populations, where the size of the dots represents the percentage of cells expressing the marker and the color indicates the average expression level. (E) Bar graphs showing the number of interactions and interaction strength between immune cell populations in the control, Anti_Ccr8, and KO_Ccr8 groups. (F) Network plots showing the interactions between immune cells in the control, Anti_Ccr8, and KO_Ccr8 groups, with nodes representing immune cell populations and edges representing interactions. (G) Bar chart showing the relative information flow between immune cells in the control, Anti_Ccr8, and KO_Ccr8 groups. (H) Interaction matrix showing the p-value and the strength of communication between different immune cell populations in response to CCR8 inhibition. Each row and column represent different immune cell subsets, with the color intensity indicating the level of communication.
