Table 3 Genome wide significant SNPs (p < 5 × 10− 8) identified in the GWAS. MAF is for GRC GOM cohort. GRCh37 hg19 genome Assembly.
Phenotype | SNP | Chrom. | Position (BP, GRCh37) | Effect Allele (A1) | MAF (A1) | Gene | N | BETA | P-value |
|---|---|---|---|---|---|---|---|---|---|
PC 2 | rs17130484 | 1 | 68,581,840 | C | 0.060 | WLS/GNG12-AS1 (intron) | 592 | −1.22 | 4.13 × 10− 08 |
PC 2 | rs10889966 | 1 | 73,064,758 | G | 0.016 | (upstream NEGR1) | 593 | −2.69 | 1.30 × 10− 10 |
PC 2 | rs17189035 | 1 | 211,657,371 | A | 0.034 | RD3 (intron) | 595 | −1.57 | 2.71 × 10− 08 |
PC 2 | rs13405142 | 2 | 41,556,281 | A | 0.024 | (intergenic SLC8A1-PKDCC) | 597 | −1.91 | 1.83 × 10− 08 |
PC 1 | rs7579047 | 2 | 228,535,921 | A | 0.016 | (downstream SLC19A3) | 597 | −2.94 | 3.44 × 10− 08 |
PC 1 | rs7578840 | 2 | 228,546,339 | A | 0.014 | (downstream SLC19A3) | 596 | −3.20 | 4.95 × 10− 09 |
PC 1 | rs12105620 | 2 | 228,548,897 | G | 0.012 | SLC19A3 (3’UTR) | 597 | −3.32 | 2.17 × 10− 09 |
PC 2 | rs7621671 | 3 | 74,906,533 | G | 0.011 | (upstream CNTN3) | 594 | −2.97 | 4.44 × 10− 08 |
PC 2 | rs2305990 | 3 | 101,520,537 | A | 0.010 | NXPE3 (synonymous) | 596 | −3.25 | 6.56 × 10− 09 |
PC 1 | rs9658167 | 6 | 35,394,080 | A | 0.013 | PPARD (3’UTR) | 597 | −2.99 | 1.47 × 10− 08 |
PC 2 | rs1325547 | 6 | 40,232,556 | A | 0.011 | (downstream LRFN2) | 597 | −3.16 | 4.79 × 10− 09 |
HOP_DISCRIM | rs817826 | 9 | 110,156,300 | G | 0.156 | (intergenic RAD23B-KLF4) | 593 | −0.37 | 2.71 × 10− 09 |
PC 1 | rs17138790 | 16 | 5,928,608 | C | 0.029 | RBFOX1 (intron) | 597 | −1.94 | 4.24 × 10− 08 |
