Table 4 Suggestively significant (p < 1 × 10− 5) SNPs from the GRC GOM cohort that reach nominal significance (p < 0.05) in the QIMR twin cohort and their associated cognitive measures.
Phenotype | Chrom. | SNP | GOM Effect Size (β) | GOM P-value | GOM MAF | Replication Test | Replication Effect Size (β) | Replication P-value | Replication MAF |
|---|---|---|---|---|---|---|---|---|---|
Memory Based Cognitive Tests | |||||||||
WAIS_LNST | 18 | rs9948718 | 0.89 | 8.25 × 10− 6 | 0.146 | WAIS_LNST | 0.40 | 3.96 × 10− 2 | 0.132 |
PCs | |||||||||
PC 2 | 1 | rs17130484 | −1.22 | 4.13 × 10− 8 | 0.060 | WASI_IQ | 2.03 | 8.64 × 10− 3 | 0.065 |
PC 2 | 1 | rs17189035 | −1.57 | 2.71 × 10− 8 | 0.034 | WAIS_LNST | −0.59 | 3.52 × 10− 2 | 0.044 |
PC 2 | 3 | rs1516398 | −0.59 | 7.14 × 10− 6 | 0.232 | WASI_IQ | −0.95 | 3.39 × 10− 2 | 0.244 |
PC 2 | 3 | rs2728030 | −0.59 | 6.80 × 10− 6 | 0.231 | WASI_IQ | −0.92 | 3.81 × 10− 2 | 0.245 |
PC 3 | 4 | rs1438371 | −1.86 | 4.36 × 10− 7 | 0.021 | WASI_IQ | 3.32 | 4.52 × 10− 2 | 0.017 |
PC 1 | 4 | rs1438371 | −1.90 | 8.36 × 10− 6 | 0.021 | WASI_IQ | 3.32 | 4.52 × 10− 2 | 0.017 |
PC 1 | 5 | rs17830827 | −1.22 | 2.15 × 10− 6 | 0.055 | WASI_IQ | −2.39 | 3.66 × 10− 3 | 0.064 |
PC 1 | 5 | rs2071161 | −0.98 | 1.87 × 10− 6 | 0.089 | WAIS_LNST | 0.41 | 2.55 × 10− 2 | 0.097 |
PC 1 | 5 | rs11739136 | −0.98 | 1.93 × 10− 6 | 0.090 | WAIS_LNST | 0.40 | 2.89 × 10− 2 | 0.098 |
PC 2 | 8 | rs10808637 | −1.35 | 6.06 × 10− 6 | 0.031 | WAIS_LNST | −0.64 | 1.25 × 10− 2 | 0.035 |
PC 2 | 8 | rs10092485 | −1.31 | 7.49 × 10− 6 | 0.033 | WAIS_LNST | −0.60 | 1.96 × 10− 2 | 0.035 |
PC 1 | 9 | rs16910952 | −1.89 | 6.24 × 10− 6 | 0.021 | WAIS_INFO | −0.99 | 4.82 × 10− 3 | 0.026 |
PC 2 | 9 | rs7029019 | −1.29 | 4.80 × 10− 6 | 0.044 | WAIS_LNST | −0.67 | 1.76 × 10− 2 | 0.035 |
PC 2 | 9 | rs16930907 | −0.96 | 5.29 × 10− 6 | 0.072 | WAIS_INFO | 0.67 | 2.73 × 10− 2 | 0.044 |
PC 2 | 12 | rs7301862 | −1.12 | 2.60 × 10− 7 | 0.062 | WASI_IQ | −1.54 | 3.66 × 10− 2 | 0.071 |
PC 2 | 14 | rs9323346 | −0.61 | 8.20 × 10− 6 | 0.195 | WASI_IQ | −1.88 | 1.48 × 10− 4 | 0.192 |
PC 3 | 14 | rs12888097 | −0.54 | 5.53 × 10− 6 | 0.252 | WAIS_INFO | 0.29 | 4.63 × 10− 2 | 0.223 |
PC 1 | 17 | rs12936983 | −1.42 | 1.00 × 10− 6 | 0.045 | WASI_IQ | −1.86 | 4.77 × 10− 2 | 0.042 |
