Fig. 4 | Scientific Reports

Fig. 4

From: siRNA-mediated inhibition of NTT-MMP-2 reduces oxidative stress and apoptotic signaling in an ex vivo model of ischemia/reperfusion injury

Fig. 4

Changes of heart rate (A) and RPP (calculated as the product of the heart rate and left ventricular developed pressure (heart rate x left ventricular developed pressure/1000)) (B) during the experiment. Recovery of heart mechanical function (difference between RPP at 25th and 77th min of perfusion expressed as a percentage of RPP recovery) (C). LDH activity in coronary effluents (D). Correlation between NTT-MMP-2 activity in mitochondrial fraction and LDH activity (E), and HR (F).*p < 0.05 Aero vs I/R, # p < 0.05 I/R vs I/R + siRNA.

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