Table 3 Formulation design of aripiprazole NLCs.

From: Design and optimization of intranasal aripiprazole-loaded nanostructured lipid carriers for enhanced brain targeting in schizophrenia: in vitro and ex vivo evaluation

Design

32 factorial design

Range

Factor1

Lipid phase

5–10%

Liquid lipid

2.5 to 5%

Solid lipid

2.5 to 5%

Factor2

Smix

20–50%

Surfactant

13.33 to 33.33%

Co-surfactant

6.66 to 16.66%

Response 1

% Drug loading

Response 2

Entrapment efficiency (%)

Response 3

Particle size(nm)

Levels

3

Formulations

9

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