Table 7 Analysis of variance table [partial sum of squares – type III].

From: Design and optimization of intranasal aripiprazole-loaded nanostructured lipid carriers for enhanced brain targeting in schizophrenia: in vitro and ex vivo evaluation

Source

Sum of squares

Df

Mean square

F value

P-value Prob > F

Significant / Not significant

Response 1

Polynomial

Drug loading (%)

Model

294.426

3

98.142

113.35

< 0.0001

Significant

A-A

46.1261

1

46.126

53.273

0.0008

-

B-B

212.677

1

212.67

245.633

< 0.0001

-

AB

35.623

1

35.623

41.143

0.0014

-

Residual

4.32916

5

0.865

  

-

Cor Total

298.755

8

   

-

Response 2

Linear model

Entrapment efficiency (%)

Model

4349.83

2

2174.91

5.69185

0.0411

Significant

A-A

315.274

1

315.274

0.82509

0.3987

-

B-B

4034.55

1

4034.55

10.5586

0.0175

-

Residual

2292.66

6

382.11

  

-

Cor Total

6642.49

8

   

-

Response 3

Polynomial

Particle size (nm)

Model

15910.9

3

5303.63

68.3681

0.0002

Significant

A-A

13,824

1

13,824

178.203

< 0.0001

-

B-B

1491.53

1

1491.53

19.227

0.0071

-

AB

595.36

1

595.36

7.67467

0.0394

-

Residual

387.873

5

77.5747

  

-

Cor total

16298.8

8

   

-

  1. A-A: lipid phase, B-B: aqueous phase, AB: formulation, Df – degrees of freedom, all factors with *p* < 0.05 were considered statistically significant.
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