Table 3 Inhibitory effects of target compounds AS-1: AS-16 on the growth of human cancer cells.

From: In-silico studies, synthesis, and pharmacological screening of novel multitarget diphenylpyrazole scaffold as EGFR/BRAF and cyclooxygenase-2 inhibitors

Comp.

Antiproliferative activity IC50 ± SEM (µM)

PaCa-2

A-549

MCF-7

PC-3

HT-29

AS-1

8.53

±

1.49

7.9

±

1.18

16.94

±

1.02

17.16

±

1.19

19.74

±

2.14

AS-2

10.88

±

1.9

9.25

±

1.87

17.98

±

1.5

17.97

±

2.13

20.03

±

3.61

AS-3

20.52

±

1.78

15.51

±

0.76

21.06

±

1.53

27.07

±

1.41

25.82

±

1.6

AS-4

22.02

±

1.15

18.8

±

1.34

21.57

±

1.03

33.44

±

1.61

26.28

±

2.93

AS-5

27.81

±

1.5

24.58

±

1.39

34.08

±

1.6

38.6

±

1.29

32.29

±

1.31

AS-6

31.5

±

2.09

25.92

±

0.8

35.38

±

0.77

47.96

±

2.03

37.25

±

0.5

AS-7

11.45

±

2.13

11.13

±

1.17

18.49

±

1.47

19.24

±

2.53

21.76

±

3.33

AS-8

16.67

±

0.82

13.61

±

1.29

20.46

±

1.43

23.59

±

1.28

22.82

±

3.13

AS-9

34.94

±

2.3

27.94

±

1.65

37.61

±

1.63

53.7

±

1.07

42.52

±

1.89

AS-10

35.44

±

0.9

33.55

±

0.87

38.66

±

1.29

54.37

±

1.56

48.33

±

1.34

AS-11

27.38

±

2.23

23.98

±

1.94

32.55

±

1.56

36.22

±

2.39

31.42

±

3.63

AS-12

34.16

±

1.37

26.91

±

0.84

35.44

±

1.42

51.18

±

2.09

39.44

±

1.97

AS-13

28.71

±

0.94

25.66

±

1.99

34.64

±

1.64

47.65

±

1.09

33.74

±

0.87

AS-14

7.7

±

1.52

6.92

±

1.98

10.27

±

0.73

16.02

±

1.41

10.66

±

1.25

AS-15

24.86

±

0.86

22.08

±

1.93

23.71

±

1.52

33.66

±

2.17

27.02

±

0.47

AS-16

26.28

±

1.53

22.27

±

1.34

31.35

±

0.97

36.21

±

0.99

29.54

±

2.91

  1. IC50 values expressed in µM. Data represent mean ± standard error.