Table 3 Inhibitory effects of target compounds AS-1: AS-16 on the growth of human cancer cells.
Comp. | Antiproliferative activity IC50 ± SEM (µM) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PaCa-2 | A-549 | MCF-7 | PC-3 | HT-29 | |||||||||||
AS-1 | 8.53 | ± | 1.49 | 7.9 | ± | 1.18 | 16.94 | ± | 1.02 | 17.16 | ± | 1.19 | 19.74 | ± | 2.14 |
AS-2 | 10.88 | ± | 1.9 | 9.25 | ± | 1.87 | 17.98 | ± | 1.5 | 17.97 | ± | 2.13 | 20.03 | ± | 3.61 |
AS-3 | 20.52 | ± | 1.78 | 15.51 | ± | 0.76 | 21.06 | ± | 1.53 | 27.07 | ± | 1.41 | 25.82 | ± | 1.6 |
AS-4 | 22.02 | ± | 1.15 | 18.8 | ± | 1.34 | 21.57 | ± | 1.03 | 33.44 | ± | 1.61 | 26.28 | ± | 2.93 |
AS-5 | 27.81 | ± | 1.5 | 24.58 | ± | 1.39 | 34.08 | ± | 1.6 | 38.6 | ± | 1.29 | 32.29 | ± | 1.31 |
AS-6 | 31.5 | ± | 2.09 | 25.92 | ± | 0.8 | 35.38 | ± | 0.77 | 47.96 | ± | 2.03 | 37.25 | ± | 0.5 |
AS-7 | 11.45 | ± | 2.13 | 11.13 | ± | 1.17 | 18.49 | ± | 1.47 | 19.24 | ± | 2.53 | 21.76 | ± | 3.33 |
AS-8 | 16.67 | ± | 0.82 | 13.61 | ± | 1.29 | 20.46 | ± | 1.43 | 23.59 | ± | 1.28 | 22.82 | ± | 3.13 |
AS-9 | 34.94 | ± | 2.3 | 27.94 | ± | 1.65 | 37.61 | ± | 1.63 | 53.7 | ± | 1.07 | 42.52 | ± | 1.89 |
AS-10 | 35.44 | ± | 0.9 | 33.55 | ± | 0.87 | 38.66 | ± | 1.29 | 54.37 | ± | 1.56 | 48.33 | ± | 1.34 |
AS-11 | 27.38 | ± | 2.23 | 23.98 | ± | 1.94 | 32.55 | ± | 1.56 | 36.22 | ± | 2.39 | 31.42 | ± | 3.63 |
AS-12 | 34.16 | ± | 1.37 | 26.91 | ± | 0.84 | 35.44 | ± | 1.42 | 51.18 | ± | 2.09 | 39.44 | ± | 1.97 |
AS-13 | 28.71 | ± | 0.94 | 25.66 | ± | 1.99 | 34.64 | ± | 1.64 | 47.65 | ± | 1.09 | 33.74 | ± | 0.87 |
AS-14 | 7.7 | ± | 1.52 | 6.92 | ± | 1.98 | 10.27 | ± | 0.73 | 16.02 | ± | 1.41 | 10.66 | ± | 1.25 |
AS-15 | 24.86 | ± | 0.86 | 22.08 | ± | 1.93 | 23.71 | ± | 1.52 | 33.66 | ± | 2.17 | 27.02 | ± | 0.47 |
AS-16 | 26.28 | ± | 1.53 | 22.27 | ± | 1.34 | 31.35 | ± | 0.97 | 36.21 | ± | 0.99 | 29.54 | ± | 2.91 |