Table 4 Effects of selected synthetic compounds on tubulin Polymerization, FAK, EGFR, and BRAF.

From: In-silico studies, synthesis, and pharmacological screening of novel multitarget diphenylpyrazole scaffold as EGFR/BRAF and cyclooxygenase-2 inhibitors

Compound

(Tubulin) Effect

(AU*)

(FAK)

IC50 ± SEMa

(µM)

EGFR inhibition

IC50 ± SEM (µM)

BRAF

inhibition

IC50 ± SEM (µM)

AS-1

2595±164

17.1±0.9

5.9±1.7

18.5±1.9

AS-2

2420±129

15.9±1.7

5.6±1.5

17.5±0.6

AS-14

2440±120

12.2±0.8

2.5±0.4

7.4±1.6

Erlotinib

-

7.5±0.8

0.05±0.01

0.07±0.01

DPBSb

2711±106

-

 

-

Vincristinec

751±119

-

 

-

Docetaxelc

4461±145

-

 

-

  1. *AU = arbitrary units; (a) Data are mean ± S.E. (n = 3); (b) Negative control; (c) Positive control.
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