Table 2 Cox proportional hazards analysis of overall survival by metastatic site.

Age

0.95 (0.91–0.99)

0.01

1.01 (0.97–1.06)

0.56

1.01 (0.96–1.05)

0.84

IMDC (poor vs intermediate)

2.51 (0.59–10.66)

0.21

2.24 (0.83–6.03)

0.11

0.94 (0.34–2.63)

0.91

1^st　line therapy (IO–TKI vs IO–IO)

1.84 (0.59–5.69)

0.29

1.43 (0.52–3.94)

0.49

0.37 (0.13–1.02)

0.055

KPS (<80 vs ≧80)

9.26 (1.79–47.9)

0.008

1.19 (0.25–5.67)

0.83

1.61 (0.55–4.74)

0.38

Age

1.00 (0.89-1.12)

0.97

0.98 (0.95-1.00)

0.06

0.99 (0.90-1.09)

0.82

IMDC (poor vs intermediate)

1.89 (0.48-7.50)

0.36

2.71 (1.53-4.83)

0.0007

11.23 (0.44-283.7)

0.14

1^st　line therapy (IO–TKI vs IO–IO)

0.14 (0.02-0.86)

0.033

0.40 (0.22-0.73)

0.003

3.98 (0.42-37.3)

0.23

KPS (<80 vs ≧80)

0.65 (0.08-5.52)

0.69

0.48 (0.22-1.04)

0.06

9.42 (0.83-106.9)

0.07