Fig. 10 | Scientific Reports

Fig. 10

From: Immunoinformatics-based design of a next generation multi-epitope vaccine candidate against Shigella boydii using a hierarchical subtractive proteomics approach

Fig. 10

C-ImmSim immunization simulation results for the three doses of MEV construct: (A) Immunoglobulin production represented by color-coded peaks. (B) Cytokine and interleukin profiles highlighting elevated levels of IFN-γ and IL-2 post-vaccination. (C) State-wise distribution of the T-helper cell population. (D) Macrophage population distribution across different functional states. (E) Distribution of B-cell populations across various states. (F) Activation of Th1-mediated immune responses. (G) Temporal evolution of T-helper cells during the simulation. (H) B-cell population dynamics showing enhanced diversity and class-switching potential. (I) Generation and activity dynamics of cytotoxic T cells.

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