Table 2 Selected cytotoxic T lymphocyte (CTL) epitopes for vaccine construction targeting S. boydii.
Epitope | Protein | Allele | Position | Antigenicity | Immunogenicity |
|---|---|---|---|---|---|
TNYFEFYLPYYW | LPS-assembly protein LptD | HLA-B*44:03 HLA-B*44:02 HLA-A*29:02 HLA-A*23:01 HLA-A*24:02 HLA-B*18:01 HLA-C*07:02 HLA-B*57:01 HLA-A*30:02 | 238–249 | 2.0628 | 0.29798 |
YYWNIAPNMDAT | LPS-assembly protein LptD | HLA-C*07:02 | 247–258 | 1.7835 | 0.09227 |
PYYWNIAPNMDA | LPS-assembly protein LptD | HLA-C*14:02 HLA-C*07:02 | 246–257 | 1.6889 | 0.23096 |
TTNYFEFYLPYY | LPS-assembly protein LptD | HLA-A*01:01 HLA-A*29:02 HLA-A*30:02 HLA-A*26:01 HLA-A*11:01 HLA-B*18:01 HLA-A*25:01 HLA-C*07:02 | 237–248 | 1.5173 | 0.29412 |
TTTNYFEFYLPY | LPS-assembly protein LptD | HLA-A*01:01 HLA-A*29:02 HLA-A*26:01 HLA-A*11:01 HLA-B*18:01 HLA-A*30:02 HLA-C*07:02 HLA-A*25:01 | 236–247 | 1.4021 | 0.30867 |
PIFYSPYLQLPV | Cell division protein FtsZ | HLA-C*07:02 HLA-C*08:02 HLA-C*14:02 HLA-C*07:01 | 209–220 | 1.2774 | -0.2769 |
GYTQTLEPRAQY | Cell division protein FtsZ | HLA-A*01:01 HLA-A*29:02 | 503–514 | 1.1626 | 0.0238 |
