Fig. 3 | Scientific Reports

Fig. 3

From: Expression and function of CYP enzymes and hepatobiliary transporters in an improved long-term sandwich culture hepatocyte model

Fig. 3

Activities of CYP enzymes in SPHH, SPHH-5C and PHH-5C hepatocyte cultures up to 21 days. The following CYP enzymes are presented: (a) CYP1A2, (b) CYP2B6, (c) CYP2C8, (d) CYP2C9, (e) CYP2C19, (f) CYP2D6 and (g) CYP3A4. D0 values are determined in the cell suspension before seeding. Representative graphs from single-donor hepatocytes (lot: IRZ). Data is presented as Mean ± SD (n = 3 of each condition). Two-way ANOVA with Tukey’s multiple comparison tests (p < 0.05).

Back to article page