Fig. 4 | Scientific Reports

Fig. 4

From: Expression and function of CYP enzymes and hepatobiliary transporters in an improved long-term sandwich culture hepatocyte model

Fig. 4

Active uptake clearance values in SPHH, SPHH-5C and PHH-5C hepatocyte cultures up to 21 days. Specific uptake transporter substrates are the following: (a) GCDC for NTCP, (b) ketoprofen for OAT2, (c) rosuvastatin for OATPs, (d) sumatriptan for OCT1. Representative graphs from pooled-donor hepatocytes (lot: UDT). Data is presented as Mean ± SD (n = 3 of each condition). Two-way ANOVA with Dunnett’s multiple comparison tests (p < 0.05).

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