Retraction of: Scientific Reports https://doi.org/10.1038/srep42106, published online 09 February 2017
The Editors have retracted this Article.
After publication, concerns were raised regarding highly similar images within the Article and with another publication from the same authors1. Specifically:
-
the H&E image in the Paclitaxel + TTT-28 in Figure 6B of this article appears to overlap the H&E image in the DOX in Figure 6B of1;
-
the H&E image in the Vehicle in Figure 6B of this article appears to overlap the H&E image in the Vehicle in Figure 6A of1;
-
the H&E image in the TTT-28 in Figure 6C of this article appears to overlap the H&E image in the Vehicle in Figure 6B of1;
-
the ABCB1 image in the Paclitaxel in Figure 6C of this article appears to overlap the ABCB1 image in the DOX-TNP in Figure 6B of1;
-
the Active Caspase-3 image in the Vehicle in Figure 6C of this article appears to overlap the Caspase-3 image in the Vehicle in Figure 6B of1;
-
the Active Caspase-3 image in the TTT-28 in Figure 6C of this article appears to overlap the Caspase-3 image in the TNP in Figure 6B of1;
-
the Active Caspase-3 image in the TTT-28 in Figure 6B of this article appears to overlap the Caspase-3 image in the Vehicle in Figure 6A of1;
-
the Cleaved PARP-1 image in the TTT-28 in Figure 6B of this article appears to overlap the PARP image in the TNP in Figure 6A of1;
-
the Cleaved PARP-1 image in the Vehicle in Figure 6B of this article appears to overlap the PARP image in the TNP in Figure 6A of1;
-
the Cleaved PARP-1 image in the Vehicle in Figure 6C in this article appears to overlap PARP image in TNP in Figure 6B in1;
-
the H&E image in the Vehicle in Figure 6B in this article appears to overlap the H&E image in the TTT-28 in Figure 6B of this article.
The Authors confirmed similarities but were unable to provide an adequate explanation to the concerns raised. The Editors therefore no longer have confidence in the presented data.
Additionally, according to the data presented in Figures 3A and 4A, the tumour burden in mice exceeded the limits stated in the NIH Guidelines for Humane Endpoints in Animal Study Proposals.
Yi-Jun Wang, Bhargav A. Patel, Yun-Kai Zhang, Guan-Nan Zhang, Suresh V. Ambudkar, Tanaji T. Talele and Zhe-Sheng Chen disagree with the retraction. Nagaraju Anreddy, Satyakam Singh, Suneet Shukla, and Amal Kaddoumi did not respond to the correspondence from the Editors about this retraction. The Editors have not been able to obtain a current email address for author Saeed Alqahtani.
Reference
Wang, Y. J. et al. Tea nanoparticle, a safe and biocompatible nanocarrier, greatly potentiates the anticancer activity of doxorubicin. Oncotarget 7(5), 5877 (2015).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Wang, YJ., Patel, B.A., Anreddy, N. et al. Retraction Note: Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1. Sci Rep 15, 45670 (2025). https://doi.org/10.1038/s41598-025-33613-3
Published:
Version of record:
DOI: https://doi.org/10.1038/s41598-025-33613-3
