Table 2 List of 53 SDM traits after one-hot encoding of qualitative traits.
SDM ID | Test name | Parameter ID | Parameter name | High in male or female | Data type | Biological systems annotated by MP ontology | Trait type | − log10(p-value) | Corrected PC1 factor loading |
|---|---|---|---|---|---|---|---|---|---|
1 | PAT | PAT_015 | Adrenal gland to body weight ratio (Ad BW) | Female | Quantitative | Endocrine/exocrine gland phenotype | External | 6.705 | 0.972 |
2 | DXA | DXA_006 | Lean mass | Male | Quantitative | Growth/size/body region phenotype | External | 5.658 | − 0.956 |
3 | ACS | ACS_016 | Body weight 10w | Male | Quantitative | Growth/size/body region phenotype | External | 5.485 | − 0.953 |
4 | PAT | PAT_022 | Pituitary to body weight ratio (Pituitary BW) | Female | Quantitative | Nervous system phenotype | External | 5.408 | 0.951 |
5 | PAT | PAT_014 | Adrenal gland – sum | Female | Quantitative | Endocrine/exocrine gland phenotype | External | 5.400 | 0.951 |
6 | GRS | GRS_013 | Body weight 09w 02 | Male | Quantitative | Growth/size/body region phenotype | External | 5.044 | − 0.943 |
7 | CSD | CSD_088 | Body weight 09w 01 | Male | Quantitative | Growth/size/body region phenotype | External | 5.044 | − 0.943 |
8 | DXA | DXA_002 | Body weight 14w | Male | Quantitative | Growth/size/body region phenotype | External | 4.952 | − 0.940 |
9 | PAT | PAT_013 | Right adrenal gland | Female | Quantitative | Endocrine/exocrine gland phenotype | External | 4.765 | 0.935 |
10 | IPG | IPG_001 | Body weight 13w | Male | Quantitative | Growth/size/body region phenotype | External | 4.716 | − 0.934 |
11 | PAT | PAT_021 | Pituitary | Female | Quantitative | Nervous system phenotype | External | 4.489 | 0.926 |
12 | PAT | PAT_001 | Body weight 18w_02 | Male | Quantitative | Growth/size/body region phenotype | External | 4.390 | − 0.923 |
13 | CBC | CBC_005 | Alkaline phosphatase (ALP) | Female | Quantitative | Homeostasis/metabolism phenotype | Internal | 4.303 | 0.920 |
14 | PAT | PAT_009 | Spleen weight to body weight ratio (SPW BW) | Female | Quantitative | Immune system phenotype | External | 3.759 | 0.896 |
15 | CSD | CSD_089 | Body mass index (BMI) | Male | Quantitative | Growth/size/body region phenotype | External | 3.480 | − 0.881 |
16 | CSD | CSD_013_M_type | Head morphology - M type | Male | Qualitative | Growth/size/body region phenotype | External | 3.235 | − 0.865 |
17 | CSD | CSD_013_F_type | Head morphology - F type | Female | Qualitative | Growth/size/body region phenotype | External | 3.235 | 0.865 |
18 | CSD | CSD_033_M_type | Genitalia morphology - M type | Male | Qualitative | Reproductive system phenotype | External | 3.235 | − 0.865 |
19 | CSD | CSD_033_F_type | Genitalia morphology - F type | Female | Qualitative | Reproductive system phenotype | External | 3.235 | 0.865 |
20 | DXA | DXA_009 | BMC/Body weight | Female | Quantitative | Skeleton phenotype | External | 3.078 | 0.853 |
21 | PAT | PAT_012 | Left adrenal gland | Female | Quantitative | Endocrine/exocrine gland phenotype | External | 3.013 | 0.848 |
22 | PAT | PAT_006 | Liver weight (LIW) | Male | Quantitative | Liver/biliary system phenotype | External | 2.712 | − 0.821 |
23 | DXA | DXA_001 | Body length 14w | Male | Quantitative | Growth/size/body region phenotype | External | 2.684 | − 0.818 |
24 | IMM | IMM_002 | Body weight 18w_01 | Male | Quantitative | Growth/size/body region phenotype | External | 2.613 | − 0.810 |
25 | PAT | PAT_004 | Left kidney weight (LKW) | Male | Quantitative | Renal/urinary system phenotype | External | 2.589 | − 0.807 |
26 | IPG | IPG_002_60 | Blood glucose concentration (60 min) | Male | Quantitative | Homeostasis/metabolism phenotype | Internal | 2.484 | − 0.795 |
27 | CBC | CBC_017 | Triglycerides (TG) | Male | Quantitative | Homeostasis/metabolism phenotype | Internal | 2.255 | − 0.765 |
28 | IMM | IMM_003 | Spleen weight/BW | Female | Quantitative | Immune system phenotype | External | 2.206 | 0.758 |
29 | CBC | CBC_019 | Iron (Fe) | Female | Quantitative | Homeostasis/metabolism phenotype | Internal | 2.151 | 0.749 |
30 | XRY | XRY_001_Yes | Baculum - Yes | Male | Qualitative | Reproductive system phenotype | External | 2.100 | − 0.741 |
31 | XRY | XRY_001_No | Baculum - No | Female | Qualitative | Reproductive System phenotype | External | 2.100 | 0.741 |
32 | XRY | XRY_015_M_type | Pelvis - M type | Male | Qualitative | Skeleton phenotype | External | 2.100 | − 0.741 |
33 | XRY | XRY_015_F_type | Pelvis - F type | Female | Qualitative | Skeleton phenotype | External | 2.100 | 0.741 |
34 | PAT | PAT_008 | Spleen weight (SPW) | Female | Quantitative | Immune system phenotype | External | 2.078 | 0.737 |
35 | GRS | GRS_011 | Forelimb and hindlimb grip strength normalized against body weight | Female | Quantitative | Behavior/neurological phenotype | External | 2.039 | 0.730 |
36 | CBC | CBC_021 | Glycosylated hemoglobin A1c (HbA1c) | Male | Quantitative | Hematopoietic system phenotype/homeostasis/metabolism phenotype | Internal | 2.031 | − 0.729 |
37 | IPG | IPG_002_120 | Blood glucose concentration (120 min) | Male | Quantitative | Homeostasis/metabolism phenotype | Internal | 1.964 | − 0.717 |
38 | PAT | PAT_002 | Right kidney weight (RKW) | Male | Quantitative | Renal/urinary system phenotype | External | 1.895 | − 0.704 |
39 | CSD | CSD_087 | Body length 09w | Male | Quantitative | Growth/size/body region phenotype | External | 1.881 | − 0.701 |
40 | IPG | IPG_003 | Glucose area under the curve (AUC) | Male | Quantitative | Homeostasis/metabolism phenotype | Internal | 1.863 | − 0.697 |
41 | CBC | CBC_008 | Albumin (ALB) | Female | Quantitative | Homeostasis/metabolism phenotype | Internal | 1.769 | 0.678 |
42 | GRS | GRS_005 | Forelimb grip strength normalized against body weight | Female | Quantitative | Behavior/neurological phenotype | External | 1.637 | 0.647 |
43 | DXA | DXA_007 | Fat mass | Male | Quantitative | Adipose tissue phenotype | External | 1.576 | − 0.632 |
44 | IMM | IMM_005 | NKT cells (panel A) | Female | Quantitative | Hematopoietic system phenotype immune system phenotype | Internal | 1.543 | 0.623 |
45 | PAT | PAT_010 | Heart weight (HW) | Male | Quantitative | Cardiovascular system phenotype | External | 1.492 | − 0.609 |
46 | IPG | IPG_002_30 | Blood glucose concentration (30 min) | Male | Quantitative | Homeostasis/metabolism phenotype | Internal | 1.462 | − 0.600 |
47 | CBC | CBC_001 | Lactate dehydrogenase (LDH) | Male | Quantitative | Homeostasis/metabolism phenotype | Internal | 1.444 | − 0.595 |
48 | IMM | IMM_014 | CD4 Effector Memory NKT (CD4 CD44 + CD62L- NKT) | Female | Quantitative | Hematopoietic system phenotype/immune system phenotype | Internal | 1.400 | 0.582 |
49 | CBC | CBC_014 | HDL-cholesterol (HDL-C) | Male | Quantitative | Homeostasis/metabolism phenotype | Internal | 1.369 | − 0.573 |
50 | CSD | CSD_017 | Tail length | Male | Quantitative | Limb/digit/tail phenotype | External | 1.368 | − 0.572 |
51 | IMM | IMM_013 | CD4 Central Memory NKT (CD4 CD44 + CD62L + NKT) | Male | Quantitative | Hematopoietic system phenotype/immune system phenotype | Internal | 1.366 | − 0.572 |
52 | CBC | CBC_016 | Total cholesterol (T-CHO) | Male | Quantitative | Homeostasis/metabolism phenotype | Internal | 1.329 | − 0.560 |
53 | IMM | IMM_001 | Spleen weight | Female | Quantitative | Immune system phenotype | External | 1.318 | 0.556 |
