Fig. 5 | Scientific Reports

Fig. 5

From: Luteolin alleviates angiogenesis in HUVECs by inhibiting VEGFA expression: integrating network pharmacology and experimental validation

Fig. 5

Luteolin suppresses angiogenesis in HUVECs. (A) Scratch assay revealed that Luteolin inhibited horizontal migration of HUVECs; (B) Quantitative analysis of relative horizontal migration rate in (A) (n = 3); (C) Transwell migration assay demonstrated Luteolin’s suppression of vertical migration in HUVECs; (D) Quantitative analysis of relative vertical migration rate in (C) (n = 3); (E) Invasion assay indicated Luteolin inhibited HUVEC invasiveness; (F) Quantitative analysis of relative invasion rate in (E) (n = 3); (G) Tube formation assay showed Luteolin suppressed tube-forming capability of HUVECs; (H) Quantitative analysis of relative tube formation rate (branching points) in (G) (n = 3); (I) Quantitative analysis of relative tube formation rate (total tube area) in (G) (n = 3). *P<0.05; **P<0.01; ***P<0.001.

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