Fig. 3 | Scientific Reports

Fig. 3

From: HMBOX1 plays a critical role in plumbagin-induced growth inhibition of hepatocellular carcinoma cells

Fig. 3

Regulation of HMBOX1 in Huh-7 cell growth depend on PI3K/Akt/m-TOR pathway. (A) Representative images for immunoblotting and quantitative analysis with targeting silence of HMBOX1 or not. (B,C) Representative images of cellular activities (B), colonies formation and numbers (C) under the condition of knockdown of HMBOX1. (D) Representative images for immunoblotting in presence of overexpression of HMBOX1 or not. (E,F) Representative images of cellular activities (E) and colonies (F) in presence of HMBOX1-overexpression. (G) Representative images for immunoblotting and quantitative analysis for mTOR, Akt, PI3K and their phosphorylation level treated with silence or overexpression of HMBOX1. Data are presented as means ± SD, n ≥ 3, *P<0.05.

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