Fig. 3 | Scientific Reports

Fig. 3

From: LncRNA PVT1 promotes proliferation, migration and invasion of cholangiocarcinoma by regulating the expression of SOCS2

Fig. 3The alternative text for this image may have been generated using AI.

Overexpression of SOCS2 inhibits the proliferation, migration, and invasion of cholangiocarcinoma cells. (A–C) Expression levels of SOCS2 in tumor tissues and their paired adjacent normal tissues. (D) Aberrant SOCS2 expression correlates with the prognosis of cholangiocarcinoma patients. (E,F) Proliferation capacity of HuCCT1 and Hccc9810 cells following SOCS2 overexpression, assessed by CCK-8 assay. (G–J) Western blot analysis showing SOCS2 expression differences in HuCCT1 and Hccc9810 cells after SOCS2 overexpression. (K–N) Migratory ability of HuCCT1 and Hccc9810 cells following SOCS2 overexpression, evaluated by wound healing assay. (O–Q) Migration ability of HuCCT1 and Hccc9810 cells after SOCS2 overexpression, determined by Transwell assay without Matrigel. (R–T) Invasive potential of HuCCT1 and Hccc9810 cells after SOCS2 overexpression, assessed by Matrigel-coated Transwell assay. *P < 0.05, **P < 0.01,*** P < 0.001.

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