Fig. 5

The role of PPIA in cancer. (A) Boxplot showing PPIA expression across pan-cancer datasets. (B) Survival analysis indicating the prognostic impact of PPIA expression. (C) Correlation between PPIA expression and 50 hallmark signaling pathways. (D, E) KEGG and GO enrichment analyses of differentially regulated genes after in silico PPIA knockout. (F) Differential expression of PPIA in lung adenocarcinoma epithelial cells.*P < 0.05, **P < 0.01, ***P < 0.001.