Fig. 3 | Scientific Reports

Fig. 3

From: Single-cell transcriptomics and spatial validation reveal dysfunction of keratinocytes and NK cells driving acne development

Fig. 3

Single-cell differentiation trajectory inference reveals dynamic remodeling of keratinocyte states during acne progression. (A) Pseudo-time differentiation trajectories of keratinocytes in NC, MA, and SA samples. (B) Two pathways of KC differentiation. (C) Proportional composition of five differentiation states (S1–S5) in NC, MA, and SA samples. (D) Distribution of subpopulations along pseudo-time trajectories. (E) State-specific trajectory trees for representative subpopulations (C2, C3, C4, C14).

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