Fig. 1 | Scientific Reports

Fig. 1

From: Distinct genomic, microenvironmental, and nephron signatures in VHL kidney cysts and tumors

Fig. 1

Cystic and cancer lesions in the kidney of a von Hippel-Lindau disease patient. (a) 3D model of all kidney cysts (purple) and tumors (orange) in the patient and the numerated tumors harvested and analysed in this study. (b) Macroscopic view of the left kidney after nephrectomy showing the multiple tumors and cysts. Sections are representative of ccRCC wiyhout prominent nucleoli at 100X magnification (WHO/ISUP nucleolar grade 2), eosinophilic cytoplasm and conspicuous nucleoli at 100X magnification (WHO/ISUP nucleolar grade 3) and cystic fluid-filled lesions with cuboidal or flat lining epithelium, sometimes characterized by clear cell changes consistent with simple renal cyst.

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