Fig. 6

Standardized trimming protocol for histological analysis of the nasal cavity in Cynomolgus monkey and Marmoset. (A, B) Sagittal gross images of the nasal cavity in Cynomolgus monkey (Female, 5.5 years) and Marmoset (Male, 1 year old), showing two trimming planes indicated by orange dashed boxes based on the external interdental region. For histological processing, the nasal cavity is trimmed along these planes, with the posterior surface oriented downward. Scale bars = 1 cm (C, D) Representative paraffin blocks and trimmed coronal sections at each level (#1 and #2) in Cynomolgus (C) and Marmoset (D). (E, F) Schematic diagrams of epithelial distribution in each section of Cynomolgus (E) and Marmoset (F), color-coded as follows: stratified squamous epithelium (SE, orange), transitional epithelium (TE, yellow), respiratory epithelium (RE, blue), and olfactory epithelium (OE, orange).