Fig. 4 | Scientific Reports

Fig. 4

From: LC2767 alleviates LPS-induced liver injury and fibrosis by regulating FXR expression, NF-κB activation, and gut microbiota

Fig. 4

Effects of LC2767 on colitis-related biomarker levels in mice orally exposed to LPS. Effects on TLR4 (A, assessed by qPCR), TNF-α (B, assessed by ELISA), and FXR expression (C, assessed by qPCR), AMPK and NF-κB activation (D, assessed by immunoblotting) and NF-κB+CD11c+ cell population (E, assessed by immunofluorescence staining) in the colon. LC2767 at a dose of 1 × 109 CFU/mouse (LCH) and saline (sLo) were orally administered once a day for 5 days to mice that were orally gavaged with LPS for 5 days. NC group was treated with saline. Data are shown in mean ± SD (n = 8). #p < 0.05 vs. NC. *p < 0.05 vs. sLo.

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