Table 1 Baseline characteristics of of patients with DLBC - PCNSL.
Attributions | Total (n = 85) | POD24 arm (n = 50) | non-POD24 arm (n = 34) | P | |
|---|---|---|---|---|---|
Gender, male/female (%) | 43 (50.6)/42 (49.40) | 28 (56.00)/22 (44.00) | 15 (44.12)/19 (55.88) | 0.37 | |
Age, Median (interquartile) | 58.00 (50.00, 66.00) | 57.00 (49.00, 66.00) | 59.50 (54.00, 65.75) | 0.52 | |
B symptom, n (%) | > 0.99 | ||||
No | 84 (98.80) | 49 (98.00) | 34 (100.00) | ||
Yes | 1 (1.20) | 1 (2.00) | 0 (0) | ||
Elevated β2M, n (%) | 0.13 | ||||
No | 66 (89.20) | 35 (83.33) | 30 (96.77) | ||
Yes | 8 (10.80) | 7 (16.67) | 1 (3.23) | ||
NA | 11 | 8 | 3 | ||
D - Dimer (µg/mL), Median (interquartile) | 0.57 (0.29, 1.19) | 0.56 (0.30, 0.56) | 0.59 (0.26, 1.32) | 0.51 | |
KPS scores | 70 (60–90) | 70 (60–82.5) | 80 (60–90) | 0.05 | |
MSKCC | 0.46 | ||||
LR | 19 (22.35) | 13 (26.00) | 6 (17.60) | ||
IR | 42 (49.41) | 22 (44.00) | 20 (58.80) | ||
HR | 24 (28.24) | 15 (30.00) | 8 (23.50) | ||
ECOG score > 2, n (%) | 0.22 | ||||
No | 73 (85.89) | 40 (80.00) | 31 (91.18) | ||
Yes | 13 (15.29) | 10 (20.00) | 3 (8.80) | ||
GCB subtype, n (%) | 0.19 | ||||
No | 47 (67.14) | 25 (60.98) | 22 (78.57) | ||
Yes | 23 (32.86) | 16 (39.02) | 6 (21.43) | ||
NA | 15 | 9 | 6 | ||
Ki 67 ≥ 80%, n (%) | 0.64 | ||||
No | 36 (46.15) | 23 (50.00) | 13 (41.90) | ||
Yes | 42 (53.85) | 23 (50.00) | 18 (58.10) | ||
NA | 7 | 4 | 3 | ||
Elevated LDH (u/L), n (%) | 0.04 | ||||
No | 70 (82.40) | 38 (76.00) | 32 (94.12) | ||
Yes | 15 (17.60) | 12 (24.00) | 2 (5.88) | ||
TG (mmol/L), Median (interquartile) | 1.20 (0.83, 1.75) | 1.26 (0.81, 1.90) | 1.20 (0.86, 1.46) | 0.42 | |
CHOL (mmol/L), Median (interquartile) | 4.46 (3.90, 5.18) | 4.49 (3.91, 5.24) | 4.38 (3.76, 5.19) | 0.81 | |
CREA (µmol/L), Median (interquartile) | 58.00 (48.00, 68.15) | 58.00 (48.00, 66.00) | 59.45 (48.00, 71.00) | 0.50 | |
Elevated protein levels in CSF, n (%) | > 0.99 | ||||
No | 9 (21.40) | 5 (23.81) | 4 (19.05) | ||
Yes | 33 (78.60) | 16 (76.19) | 17 (80.95) | ||
NA | 43 | 29 | 13 | ||
Albumin (g/L), Median (interquartile) | 40.70 (36.80, 44.05) | 40.30 (35.80, 44.30) | 40.80 (37.60, 43.93) | 0.64 | |
HbsAg positive, n (%) | 0.19 | ||||
No | 74 (87.10) | 42 (84.00) | 32 (94.12) | ||
Yes | 11 (12.90) | 8 (16.00) | 2 (5.88) | ||
Excision of intracranial tumor, n (%) | 0.01 | ||||
No | 16 (18.80) | 14 (28.00) | 2 (5.88) | ||
Yes | 69 (81.20) | 36 (72.00) | 32 (94.12) | ||
Residual parenchymal central system lymphoma, n (%) | 0.01 | ||||
no | 25 (29.40) | 9 (18.00) | 16 (47.06) | ||
yes | 60 (70.60) | 41 (82.00) | 18 (52.94) | ||
WBRT, n (%) | > 0.99 | ||||
No | 73 (89.02) | 42 (89.36) | 31 (91.18) | ||
Yes | 9 (10.98) | 5 (10.64) | 3 (8.82) | ||
NA | 3 | 3 | 0 | ||
Regimens without RTX, n (%) | 0.23 | ||||
No | 56 (69.14) | 29 (63.00) | 26 (37.00) | ||
Yes | 25 (30.86) | 17 (34.00) | 8 (23.53) | ||
NA | 4 | 4 | 0 | ||
ASCT, n(%) | > 0.99 | ||||
No | 76 (89.40) | 45 (90.00) | 30 (88.24) | ||
Yes | 9 (10.60) | 5 (10.00) | 4 (11.76) | ||
Non-responsive diseases, n (%) | 0.002 | ||||
No | 51 (68.00) | 22 (52.40) | 28 (87.50) | ||
Yes | 24 (32.0) | 20 (47.60) | 4 (12.50) | ||
NA | 10 | 8 | 2 | ||
