Table 1 Patients’ clinicopathologic characteristics.
From: Notch1+ cervical cancer cells may promote perineural invasion by secreting neurotrophin-4
Parameter | Before PSM | N=755 | P value | After PSM | N=355 | P value |
|---|---|---|---|---|---|---|
PNI+ | PNI− | PNI+ | PNI- | |||
Age, years | 55 (48.5–59) | 50 (44–56 ) | < 0.001*** | 55 (48.5–59) | 53 (47–58) | <0.001*** |
Clinical stage | 0.008** | 1 | ||||
IA2 | 0 (0%) | 4 (0.6%) | 0 (0%) | 1 (0%) | ||
IB1 | 8 (11.3%) | 183 (26.8%) | 8 (11.3%) | 31 (10.9%) | ||
IB2 | 15 (21.1%) | 170 (24.9%) | 15 (21.1%) | 55 (19.4%) | ||
IB3 | 6 (8.5%) | 61 (8.9%) | 6 (8.5%) | 34 (12.0%) | ||
IIA1 | 10 (14.1%) | 94 (13.7%) | 10 (14.1%) | 59 (10.9%) | ||
IIA2 | 8 (11.3%) | 57 (8.3%) | 8 (11.3%) | 37 (21.9%) | ||
IIB | 24 (33.8%) | 115 (16.8%) | 24 (33.8%) | 67 (23.6%) | ||
Histological type | 0.116 | 1 | ||||
Squamous cell carcinoma | 62 (87.3%) | 559 (81.7%) | 62 (87.3%) | 244 (85.0%) | ||
Adenocarcinoma | 6 (8.5%) | 111 (16.2%) | 6 (8.5%) | 36 (12.7%) | ||
Adenosquamous carcinoma | 3 (4.2%) | 14 (2.1%) | 3 (4.2%) | 4 (1.4%) | ||
Tumor size, cm | < 0.001*** | 1 | ||||
≤ 4 | 44 (62.0%) | 560 (82.0%) | 44 (62.0%) | 196 (69.0%) | ||
> 4 | 27 (38.0%) | 124 (18.0%) | 27 (38.0%) | 88 (31.0%) | ||
Lymph node metastasis | < 0.001*** | 1 | ||||
Negative | 35 (49.3%) | 548 (80.0%) | 35 (49.3%) | 100 (35.2%) | ||
Positive | 36 (50.7%) | 136 (20.0%) | 36 (50.7%) | 178 (62.3%) | ||
Vascular invasion | < 0.001*** | 1 | ||||
Negative | 24 (34.0%) | 413 (60.4%) | 24 (34.0%) | 114 (40.1%) | ||
Positive | 47 (66.0%) | 271 (39.6%) | 47 (66.0%) | 170 (59.9%) | ||
Depth of cervical invasion | < 0.001*** | 0.522 | ||||
< 2/3 | 8 (11.3%) | 394 (57.6%) | 8 (11.3%) | 25 (8.8%) | ||
≥ 2/3 | 63 (88.7%) | 290 (42.4%) | 63 (88.7%) | 259 (91.2%) |
