Table 1 Summary of study findings.
Behavioral domain | Test | Measure | Statistical Significance | Effect of A53T a-Syn overexpression |
|---|---|---|---|---|
Depression-like | Sucrose preference test | Sucrose preference | Interaction: F (1, 74) = 4.196, p = 0.0447 Time: F (1, 74) = 8.057, p = 0.0058 Group: F (1, 74) = 1.862, p = 0.1765 | Week 3: Null Week 6:\(\downarrow\) |
Anxiety | Novelty suppressed feeding | Latency to feeding | Interaction: F (1, 74) = 2.448, p = 0.1220 Time: F (1, 74) = 1.776, p = 0.1868 Group: F (1, 74) = 0.1237, p = 0.7260 | Week 3: Null Week 6: Null |
Open field | Time spent in the periphery | Interaction: F (1, 74) = 0.09539, p = 0.7584 Time: F (1, 74) = 8.478, p = 0.0049 Group: F (1, 74) = 0.5779, p = 0.4498 | Week 3: Null Week 6: Null | |
Recognition memory | Novel object recognition | Recognition index | Interaction: F (1, 74) = 0.3820, p = 0.5384 Time: F (1, 74) = 0.1927, p = 0.6620 Group: F (1, 74) = 0.04472, p = 0.8331 | Week 3: Null Week 6: Null |
Olfaction | Habituation—dishabituation test | Cross-habituation index | Interaction: F (1, 74) = 0.2718, p = 0.6037 Time: F (1, 74) = 2.318, p = 0.1322 Group: F (1, 74) = 2.450, p = 0.1218 | Week 3: Null Week 6: Null |
Locomotion | Open field | Total distance | Interaction: F (1, 74) = 0.2598, p = 0.6118 Time: F (1, 74) = 0.2326, p = 0.6310 Group: F (1, 74) = 7.956, p = 0.0061 | Week 3: Null Week 6:\(\downarrow\) |
Mean speed | Interaction: F (1, 74) = 0.9059, p = 0.3443 Time: F (1, 74) = 0.9379, p = 0.3360 Group: F (1, 74) = 7.982, p = 0.0061 | Week 3: Null Week 6:\(\downarrow\) | ||
Grid walking test | Slip ratio | Interaction: F (1, 74) = 1.178, p = 0.2812 Time: F (1, 74) = 0.004504, p = 0.9467 Group: F (1, 74) = 22.28, p < 0.0001 | Week 3: \(\uparrow\) Week 6:\(\uparrow\) | |
Grid walking test after L-DOPA administration | Slip ratio | Interaction: F (1, 18) = 0.6821, p = 0.4197 Injection: F (1, 18) = 4.919, p = 0.0397 Treatment: F (1, 18) = 0.3644, p = 0.5536 | L-DOPA: \(\downarrow\) Saline: Null |
