Fig. 3
From: Identification and validation of a refined CAF-Associated diagnostic signature in breast cancer
Stroma cell heterogeneity. (A) Stroma cells can be categorized into three major subpopulations: endothelial cells, pericytes, and fibroblasts. (B) Distributions of normal and cancerous samples across stroma subpopulations. (C) Distributions of different types of breast cancer across stroma subpopulations. (D) The stroma cell subpopulations were further refined based on the distributions of benign and malignant samples. UMAP plots (E) and violin plots (F) show the expression levels of selected genes. (G) Fibroblasts were extracted and subjected to dimensional reduction and clustering, yielding normal fibroblasts, iCAFs, and mCAFs, UMAP plots and violin plots show the expression levels of selected genes. (H) Trajectory reconstruction illuminates the differentiation process of fibroblasts in breast cancer. (I) Feature genes show varied expression patterns during the trajectory reconstruction. (G-K) CAFs exhibit heterogeneity in breast cancer. (L) Dot plots show the expression levels of selected genes across different CAFs subpopulations.
