Table 2 Mortality risk in the early strategy group compared to the late strategy group.

From: Impact of early initiation of renal replacement therapy in patients on venoarterial ECMO using target trial emulation with Japanese nationwide data

 

HR

95% CI

28-day mortality

 Model 1

0.77

0.67–0.89

 Model 2

0.83

0.71–0.96

 Model 3

0.59

0.53–0.68

90-day mortality

 Model 1

0.83

0.73–0.95

 Model 2

0.86

0.75–0.99

 Model 3

0.67

0.61–0.75

  1. Model 1 is a univariate Cox proportional hazards model in the crude cohort, Model 2 is a multivariate Cox proportional hazards model in the crude cohort, and Model 3 is a Cox proportional hazards model weighted by IPCW in the Target Trial Emulation. Covariates included in Model 2 and IPCW for Mode 3 are age, sex, smoking status, obesity, chronic kidney disease, Charlson comorbidity index, cardiovascular disease, unscheduled admission, Japanese ICU category, each component of the SOFA score, use of IABP, Impella, and VAD, implementation of target temperature management, use of antibiotics, vasopressors, inotropes, and loop diuretics, volume of intravenous fluids, cardiac surgery, aneurysm surgery, percutaneous coronary intervention, and exposure to nephrotoxins.
  2. HR hazard ratio, CI confidence interval.
Back to article page