Fig. 4

Three-dimensional representation of exposed regions in vaccine construct that B cell epitopes were located. The exposed regions are represented by yellow surface, and the bulk of the polyprotein is represented in grey sticks; the specific position of the exposed regions in vaccine construct are as follows: (a) residues 238–263, (b) residues 127–146, (c) residues 156–162, (d) residues 1–32.