Table 1 Result of the generation of resistant parasites to KAE609, DONE3TCl and YAT2150. *: parasites were not detected during the experiment when compound concentration was increased. **: no parasites re-emerged at day 60 upon treatment with one single lethal dose.
Compound | Number of initial parasites (compound concentration) | Method | Day of reemergence | Number of reemerged replicates |
|---|---|---|---|---|
KAE609 | 1 × 10⁸ (3×IC50) | Lethal dose | 17 | 3 |
KAE609 | 1 × 10⁹ (3×IC50) | Lethal dose | 15 | 3 |
DONE3TCl | 1 × 10⁸ (3×IC50) | Lethal dose | 28 | 1 |
DONE3TCl | 1 × 10⁹ (3×IC50) | Lethal dose | 30 | 3 |
DONE3TCl | 1 × 10⁸ (1×IC50) | Stepwise increased sub-lethal doses | * | 0 |
YAT2150 | 1 × 10⁸ (3×IC50) | Lethal dose | ** | 0 |
YAT2150 | 1 × 10⁹ (3×IC50) | Lethal dose | ** | 0 |
YAT2150 | 1 × 10⁸ (1×IC50) | Stepwise increased sub-lethal doses | * | 0 |
YAT2150 | 1 × 10⁸ (0.5×IC50) | Stepwise increased sub-lethal doses | * | 0 |
YAT2150 | 1 × 10⁸ (0.25×IC50) | Stepwise increased sub-lethal doses | * | 0 |
