Table 2 IC50values upon treatment with DONE3TCl of Dd2-Pol∂ and clones of the DONE3TCl-treated and re-emerged in vitro cultures. N/A: not applicable. p value compares each strain to the parental Dd2-Pol∂ (n = 2).

From: YAT2150 is irresistible in Plasmodium falciparum and active against Plasmodium vivax and Leishmania clinical isolates

Strain

Clone

IC50 (nM) ± SE

p value

Resistant 1 (109)

8E

100.1 ± 1.3

0.977

5F

108.3 ± 1.3

0.902

11F

57.2 ± 1.1

0.789

9H

101.4 ± 1.7

0.968

11B

65.7 ± 1.2

0.937

Resistant 2 (109)

9G

63.5 ± 1.2

0.897

2H

77.7 ± 1.4

0.695

2A

60.6 ± 1.6

0.605

1F

105.0 ± 2.2

0.896

8F

73.0 ± 1.2

0.784

Dd2-Pol∂

N/A

68.9 ± 1.1

N/A

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