Table 2 Hub genes of modules with differential expression patterns among the MDD-SI, MDD-nSI and HC groups.

From: Identification of blood transcriptome modules associated with suicidal ideation in patients with major depressive disorder

Module

Hub genes

Role of hub genes

Megenta

EIF4A3 (15), SRSF11 (14), SF3B1 (13)

RNA splicing and translation initiation.

Brown

TP53 (22), EP300 (16), TRAF6 (15), HDAC1 (15)

Repair damaged DNA, regulation of immune responses and inflammation.

Turquoise

FAU (86), RPS3 (78), RPS11 (77), RPL23 (75), RPS8 (74)

Cellular processes, including regulation of apoptosis, mRNA translation, protein synthesis.

Green

SYK (19), LYN (16), PIK3CD (15), PTPN6 (14), STAT3 (13), TYK2 (11), IL1B (10), CD8A (9), ITGB2 (9)

Inflammation and immune response, regulates signaling cascades in immune cells such as B cells, T cells, and macrophages.

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