Fig. 6
From: GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway
GNG2 overexpression suppresses CRC progression in vivo. (A) Bioluminescence images of HCT116-luc cells with different GNG2 expression in Balb/c nude mice at different time points. (B, C) body weight and bioluminescence change curves in mice with different GNG2 expression levels. (D) Immunohistochemistry staining for PI3K/AKT/mTOR signaling pathway and G0/G1 arrest in whole-brain tumor tissue sections (scale bar = 100 μm). (E) Multiplex immunofluorescence staining image of PI3K/AKT signaling pathway (PI3K and p-AKT) and G0/G1 arrest marker (CDK4) in the tumor tissue (scale bar = 200 μm).
