Fig. 7 | Scientific Reports

Fig. 7

From: Evaluation of hesperidin as a potential larvicide against Culex pipiens with computational prediction of its mode of action via molecular docking

Fig. 7

Molecular docking interactions of Hesperidin with key neuroreceptors in Culex pipiens. The blue structure represents the ligand Hesperidin, while the green surface indicates the binding pockets of the neuroreceptors. (A) Interaction of Hesperidin with Acetylcholinesterase (AChE), highlighting the fit within the enzyme’s active site. (B) Interaction of Hesperidin with Nicotinic Acetylcholine Receptor (nAChR), demonstrating the binding conformation within the receptor site. (C) Interaction of Hesperidin with Voltage-Gated Sodium Channel (VGSC) α subunit, showing the ligand nestled within the channel’s binding pocket. (D) Interaction of Hesperidin with Gamma-Aminobutyric Acid Receptor (GABAR), illustrating the multiple points of contact between the ligand and the receptor. The figure was generated using Molecular Operating Environment (MOE), version 2024.06 (Chemical Computing Group ULC, Montreal, QC, Canada; URL: https://www.chemcomp.com).

Back to article page